ZEJULA® (niraparib) - Dosing, Monitoring & Side Effects

Taking ZEJULA

Convenient once-daily dosing

ZEJULA is a once-daily oral medication, which makes it easy to fit into your schedule. With ZEJULA, you can have more of your day to focus on what matters to you. You can plan your treatment around your life, not your life around taking your treatment.1,2

Keep in mind1:

  • While ZEJULA should be taken at the same time each day, you can choose a time that is convenient for you
  • ZEJULA can be taken with or without food, which means that you are not tied to meal schedules
  • If you miss a dose of ZEJULA, you should take the next dose at your regularly scheduled time
  • ZEJULA is easy to travel with. You can keep it in your purse or carry-on bag
  • ZEJULA does not have any specific storage instructions other than that it must be kept at room temperature
ZEJULA® (niraparib) 100 mg capsules

Your doctor may customize your dose based on your individual needs.1

The recommended starting dose of ZEJULA is three 100-mg capsules once a day.

When starting treatment, your doctor will be able to evaluate whether you are likely to require early dose modification3

Monitoring how your body responds1

Your healthcare provider will keep a close eye on how ZEJULA is affecting you. He or she will check your blood pressure and heart rate monthly for the first year and as needed thereafter during treatment with ZEJULA.

Your doctor will also regularly monitor your blood cell counts because ZEJULA can cause changes in your blood cell levels. Complete blood cell counts will be monitored weekly for the first month, monthly for the next 11 months, and periodically after that to ensure that your doctor can respond quickly to any changes.

*Schedule provided as an example. Your doctor will determine how often you need blood work.

If your dose has been interrupted or changed, your blood cell counts need to be checked weekly for 4 weeks.

ZEJULA remained effective in the clinical trial, even when doses were adjusted. By working with your doctor to customize your dose of ZEJULA, you may be able to stay on and benefit from treatment longer.1,3,4

Managing potential side effects1

It's important to tell your doctor about any side effects that you experience while taking ZEJULA so he or she can help you work through them. Together, you can work to find the right dose for you. For example, if you experience nausea, your doctor may suggest taking ZEJULA before bed.1

If you experience side effects, your doctor may interrupt your treatment with ZEJULA for up to 28 days or reduce the number of capsules that you take each day. This dose adjustment or interruption is to allow your blood counts or other severe side effects to improve. Your doctor may ask you to make adjustments in the schedule of your blood tests and will determine when you can resume taking ZEJULA.1 

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References: 1. ZEJULA [package insert]. Waltham. MA: TESARO, Inc; 2018. 2. Ferrell B, Smith SL, Cullinane CA, Melancon C. Psychological well being and quality of life in ovarian cancer survivors. Cancer. 2003;98(5):1061-1071. 3. Data on file. TESARO, Inc. 4. Wang J, Zhang Z-Y, Mansoor R, et al. The exposure-response relationship of niraparib in patients with gBRCAmut and non-gBRCAmut: results from the ENGOT-OV16/NOVA trial. Poster presented at: Annual Congress of the European Society for Medical Oncology; September 8-12, 2017; Madrid, Spain. Poster 933PD.

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