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QUADRA Trial Dosing

For Treatment of Advanced HRD+ Ovarian Cancer After Three or More Chemotherapies1

The approved starting dose of ZEJULA for treatment of advanced HRD+ ovarian cancer is 300 mg/day

ZEJULA Recommended Dose Modifications for Adverse Reactions1

Adverse Reactions in QUADRA Were Consistent With Other Clinical Findings In NOVA1

Adverse reactions in QUADRA led to dose reduction or interruption, 73%1

Most frequently from:

  • Thrombocytopenia, 40%
  • Nausea, 13%
  • Fatigue, 9%
  • Anemia, 21%
  • Vomiting, 11%
  • Abdominal pain, 5%
  • Neutropenia, 11%


Discontinuation, 21%

ALT, alanine aminotransferase; AST, aspartate aminotransferase; CBC, complete blood count; CTCAE, Common Terminology Criteria for Adverse Events, version 4.02.

Efficacy data


View efficacy data for all indications

See the Data

Reference: 1. ZEJULA (niraparib). Prescribing Information. GlaxoSmithKline; 2020.